Initially launched in the US in 2000 as Radiance FN, this dermal filler was introduced in Europe in June 2004 under the name Radiesse. Radiesse® filler is a safe, FDA-approved dermal filler that gives you both immediate and long-lasting results. RADIESSE filler stimulates the body to produce new collagen and restores a healthy, natural look. This convenient treatment corrects the signs of Facial Lipoatrophy, including sunken cheeks and indentations and help to restore volume and promotes the growth of the body’s own collagen, providing lasting, but not permanent, augmentation. Radiesse® dermal filler is the only dermal-filler in the United States with two FDA-approved facial indications. In general, calcium hydroxylapatite, the functional component of Radiesse, has been safely used in the human body for over 25 years in several indications.

RADIESSE dermal filler is:

  • Stimulates the body to produce NEW COLLAGEN
  • IMMEDIATE correction in a treatment that can be performed during a lunch hour
  • LONG-LASTING, natural-looking facial restoration
  • BIOCOMP A TIBLE – no skin testing prior to treatment

RADIESSE® wrinkle filler does more than just “fill- in” lines and facial wrinkles – it replenishes volume and stimulates the production of your own natural collagen with results that last up to a year or more.


Other Fillers

Injectable fillers that are short-term and just fill in lines Time-consuming and costly touch-up treatments every 3 to 6 months Animal-derived fillers that may be rejected by the body


RADIESSE wrinkle filler, proven to stimulate the growth of your own natural collagen Instant results that last a year or more in many patients with a single RADIESSE wrinkle filler treatment Biocompatible RADIESSE wrinkle filler, which works with your body to restore facial volume

What does Radiesse contain?

Radiesse is made up of synthetic Calcium Hydroxylapatite (CaHA) microspheres suspended in a gel carrier, which is an aqueous gel that contains sodium carboxy methylcellulose, glycerin and high purity water. Radiesse is approximately 30% CaHA and 70% gel carrier by volume, The CaHA spheres are composed of calcium and phosphate ions which occur naturally in human tissue. It does not contain any animal or human-derived components.

How is it made?

A synthetic process where calcium and phosphate ions are bonded together into calciumhydroxylapatite particles.

Is a skin test required before treatment?

No. Radiesse has a biocompatible formulation. The manufacturers state that it will not produce a toxic or allergic response

Radiess treatment indications

Radiesse can be used for the treatment of:

  • Nasolabial Folds – Between the nose and mouth
  • Marionette lines – The so-called “smile lines” in corners of the mouth
  • Radial lip lines – Lines above the upper lip
  • Depressions and blemishes – Like acne scars • Shallow cheeks – Caused by fat atrophy
  • Nose and Chin – Correcting indentations, tips, bumps, and unevenness.
  • Jaw – Improving the contours of this area

Is it temporary or permanent?

Radiesse is not a permanent filler. It is a long-lasting, resorbable filler – with the effect claimed to last approximately 2 years depending on the patient and the area treated. Once injected into your skin, the smooth and spherical CaHA particles form a ‘scaffold’ which your own tissue grows new collagen cells between. The gel carrier dissolves within a few months and o ver time, the CaHA particles gradually break down and are completely metabolised by the body, leaving only the new collagen structure.

Not to be used in

Pregnancy or lactation and people with pre-existing infections. If you’re taking aspirin or other medications, please consult your physician. Radiesse should not be injected over permanent injectable implants. If you have other implants or filler materials still in place, please notify and consult your physician.

Duration of effect

When injected in soft tissue, fibrous encapsulation of the microspheres creates volume in the treatment area. Radiesse appears to provide a longer term result than pure Hyaluronic acid based fillers such as Restylane® or Perlane®as it is gradually replaced by the body’s own tissue, and slowly dissolves away over a 18 month or longer period.

Reported side effects?

There are few reported side effects from clinical trials and actual usage data. However, some common injection-related reactions may occur, such as swelling, pain, itching, discoloration and tenderness at the injection site. Some lumpiness at the injection site can occur, which is often due to incorrect placement of the product. The company claims that more serious granulomatous reactions have not yet been reported with the product.

Clinical results

Radiesse has been tested extensively in clinical trials for over 7 years, with excellent safety and efficacy results.

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